Omega and polyunsaturated FAs (PUFAs) benefit brain in cognition and dementia include reduction in CVD and stroke, reduction in the synthesis of pro-inflammatory cytokines implicated in the pathogenesis of AD, maintenance of brain cell membrane integrity and neuronal function, and reduction of β-amyloid by decreasing production and increasing clearance
The brain is vulnerable to excessive oxidative insults because of its abundant lipid content,
high energy requirements, and weak antioxidant capacity. Reactive oxygen species (ROS) increase
susceptibility to neuronal damage and functional deficits, via oxidative changes in the brain in
neurodegenerative diseases.
PEN formulation with fatty acids and antioxidants give maximum benefits to the brain for recovery.
